The Tigers (8-13, 1-6 SEC), who had lost their first six SEC games, got career highs from Rob Chubb and Josh Wallace, who finished with 18 and 17 points, respectively.
Earnest Ross had 10 points and 7 rebounds. Chris Denson added 10 points and Kenny Gabriel 13 rebounds.
Auburn went into halftime ahead 33-28 and grew that lead to double digits in the second half.
The Tigers, who hadn't shot better than 38 percent in any SEC game this season, shot 41.3 percent from the floor (26-for-63). The SEC's worst free throw shooting team went 26-for-34 from the line.
South Carolina (12-7, 3-3 SEC) went just 7-for-33 from 3-point range.
Auburn is in action again Thursday at home against Tennessee. Tipoff is 9 p.m. ET.